Combination immunotherapy with an albumin-binding interleukin-12 fusion protein that extends cytokine half-life, targets the tumor microenvironment, and enhances therapeutic efficacy

February 2025

Presented at the 2025 American Association for Cancer Research (AACR) IO Conference

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SON-1010: an albumin-binding IL-12 fusion protein that improves cytokine half-life, targets tumors, and enhances therapeutic efficacy

December 2024

Published in Frontiers in Immunology

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SB221: A proof-of-concept study to assess the combination of SON-1010 (IL12-FHAB) and atezolizumab in patients with platinum-resistant ovarian cancer: Trial in Progress

June 2024

Presented at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting

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Low Dose Interleukin-6 (SON-080) for Neuropathies: Toxicology and Clinical Plans

April 2024

Presented at the 2024 American Association of Cancer Research (AACR) Annual Meeting

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SON-1210 - a novel bifunctional IL-12 / IL-15 fusion protein that improves cytokine half-life, targets tumors, and enhances therapeutic efficacy

December 2023

Published in Frontiers in Immunology

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Interim Analysis of a Phase 1 Study Using IL12-FHAB with Optimized Pharmacokinetics

November 2023

Presented at the 2023 Connective Tissue Oncology Society (CTOS) Annual Meeting

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Clinical Development of a Novel Form of Interleukin-12 with Extended Pharmacokinetics

April 2023

Presented at the 2023 American Association of Cancer Research (AACR) Annual Meeting

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An Innovative Human Platform for Targeted Delivery of Bispecific Interleukins to Tumors

April 2022

Presented at the 2022 American Association of Cancer Research (AACR) Annual Meeting

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Toxicity Profile of Interleukin 12 Attached to a Fully Human Albumin Binding Domain (FHAB™) in Cynomolgus Macaques

May 2021

Presented at the 2021 American Association of Cancer Research (AACR) Annual Meeting

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A Novel Strategy to Produce High Level and High Purity of Bioactive IL15 Fusion Proteins from Mammalian Cells

August 2018

Protein Expression and Purification 148 (2018) 30–39

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